Wrinkles Can Slow down Oxygen Formation

Wrinkles are usually going to happen with age. But with the occurrence of ozone depletion, wrinkles can occur at younger ages. A study found that the number of oxygen can help reduce the formation of wrinkles.
A Japanese study found that an overdose of oxygen can help reduce wrinkle formation, namely by reducing tissue damage due to UVB rays.
Signs of skin damage like wrinkles and skin thickening usually be easily seen in the outermost layer of skin, called epidermis.
In that study, as reported from Medindia on Saturday (18/09/2010), researchers found that the skin is exposed to a lot of oxygen after exposure to UVB radiation, will develop wrinkles and less tissue damage.
When skin repeatedly exposed to UVB radiation, will form new blood vessels from blood vessels in the skin, called skin angiogenesis.
Several protein transcription factors that bind specific DNA sequences, play a role in angiogenesis, including hypoxia inducible factor (HIF-1) and HIF-1 subunit and vascular endothelial growth factor (VEGF).
And the results showed that the oxygen and the amount of excess oxygen within the body tissue (hyperoxia) can reduce skin damage and wrinkles caused by UVB radiation.
This research also has a surprising result, namely, involving molecules called matrix metalloproteinases (MMP). Two in particular MMP, MMP-2 and MMP-9, is expected to accelerate wrinkles by reducing the external component of skin cells.
But in this study, MMP-2 levels tended to decrease and the level of MMP-9 remains the same, even on the skin that do not receive oxygen.
According to researchers, this means that MMP-2 and MMP-9 is not a major factor in wrinkle formation and angiogenesis, at least in the early stages of skin damage caused by UVB radiation.
The results of this study have been published in the American Journal of Physiology-Regulatory, Integrative and Comparative Physiology.